|
KMID : 1161420110140090944
|
|
Journal of Medicinal Food
2011 Volume.14 No. 9 p.944 ~ p.946
|
|
|
Rosmarinus officinalis L. Essential Oil Inhibits In Vivo and In Vitro Leukocyte Migration
|
|
de Melo Gessilda Alcantara Nogueira
Grespan Renata
Fonseca Jefferson Pitelli
Farinha Thiago Oliveira
Silva Expedito Leite
Romero Adriano Lopes
Bersani-Amado Ciomar A.
Cuman Roberto Kenji Nakamura
|
|
|
Abstract
|
|
|
|
Rosmarinus officinalis L. (Lamiaceae), popularly known as rosemary, is used for food flavoring and in folk medicine as an antispasmodic, analgesic, antirheumatic, diuretic, and antiepileptic agent. Few studies have shown the anti-inflammatory effects of rosemary essential oil (REO). This study evaluated the effects of REO on leukocyte migration through in vivo leukocyte migration and in vitro chemotaxis assay. REO was analyzed by using gas chromatography?mass spectometry, and the main components identified were camphor (27.59%), 1,8-cineole (15.74%), α-pinene (16.58%), and β-myrcene (10.02%). In rats, administration of REO reduced the number of leukocytes that rolled, adhered, and migrated to the scrotal chamber after carrageenan injection. All doses of REO tested significantly inhibited leukocyte chemotaxis induced by casein. The effects of REO on leukocyte migration highlight an important mechanism of the anti-inflammatory action of rosemary.
|
|
|
KEYWORD
|
|
|
anti-inflammatory, medicinal plants, rosemary
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|